We have tested the new version of Memento 188.8.131.52 on a large model of "baby alien" from our last year's design contest Hedgehog in cage. The winner, the "Alien" model (with its cage/nest) was designed in 3ds Max and this organic shape is very detailed. Its source .max file has about 700MB, the exported .obj file is a hefty 1.6GB giant. Full detailed STL print file is also over 1GB, and thus many 3D print engines had problems handling it. It was also not easy to view or simplify this large mesh in any 3D software.
Loading this OBJ or STL model into Memento was very fast, about 2:20 min. on a plain home PC with just an integrated graphics card. The model then rotated and zoomed in real time. Individual faces could be easily selected. The native .rcm file has 700MB and it loads instantaneously(!) in Memento. Subsequent OBJ re-export of this model with 50% decimation (simplification) took about 4 minutes (there was not any visible degradation on this 50%-smaller model). You can 3D print on different 3D printers directly from Memento.
So if you need to heal, process or 3D print a large mesh model (scanned or modelled), Memento is definitely worth trying.
See Project Memento on Autodesk Beta site.